STAT2-directed pathogen responses
نویسندگان
چکیده
منابع مشابه
STAT2-directed pathogen responses
Interferons (IFNs) are a subset of cytokines that mediate innate immune responses and provide a robust first line of defense against invading pathogens. IFNs represent a family of molecules which can be divided into three main sub-families: Type I, Type II and Type III [1]. Type I IFNs predominantly consist of IFNα and IFNβ subtypes, Type II consists of the single IFNγ type, while Type III comp...
متن کاملStat2
STAT2 is unique among the STAT family of transcription factors in that its activation is driven predominantly by only two classes of cell surface receptors: Type I and III interferon receptors. As such, STAT2 plays a critical role in host defenses against viral infections. Viruses have evolved to target STAT2 by either inhibiting its expression, blocking its activity, or by targeting it for deg...
متن کاملA cytomegaloviral protein reveals a dual role for STAT2 in IFN-γ signaling and antiviral responses
A mouse cytomegalovirus (MCMV) gene conferring interferon (IFN) resistance was identified. This gene, M27, encodes a 79-kD protein that selectively binds and down-regulates for signal transducer and activator of transcription (STAT)-2, but it has no effect on STAT1 activation and signaling. The absence of pM27 conferred MCMV susceptibility to type I IFNs (alpha/beta), but it had a much more dra...
متن کاملSTAT2 phosphorylation and signaling
STAT2 is an essential transcription factor in type I IFN mediated anti-viral and anti-proliferative signaling. STAT2 function is regulated by tyrosine phosphorylation, which is the trigger for STAT-dimerization, subsequent nuclear translocation, and transcriptional activation of IFN stimulated genes. Evidence of additional STAT2 phosphorylation sites has emerged as well as novel roles for STAT2...
متن کاملMurine Stat2 is uncharacteristically divergent.
Characterization of the ability of human interferons (IFNs) to rapidly induce genes led to the identification of the first two members of the STAT (signal transducers and activators of transcription) family, Stat1 and Stat2. To study the unique role of this transcription factor in IFN signaling under more physiological conditions, murine Stat2 was isolated and found to be surprisingly divergent...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.5266